ARG41346

anti-Cytochrome P450 26A1 antibody

anti-Cytochrome P450 26A1 antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes Cytochrome P450 26A1
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Cytochrome P450 26A1
Antigen Species Human
Immunogen Synthetic peptide within aa. 50-150 of Human Cytochrome P450 26A1 (NP_000774.2).
Conjugation Un-conjugated
Alternate Names Cytochrome P450 26A1; CYP26; P450RAI1; Retinoic acid-metabolizing cytochrome; hP450RAI; Retinoic acid 4-hydroxylase; P450RAI; Cytochrome P450 retinoic acid-inactivating 1; CP26; Cytochrome P450RAI; EC 1.14.-.-

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HepG2
Observed Size 55 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1592 Human CYP26A1

Swiss-port # O43174 Human Cytochrome P450 26A1

Gene Symbol CYP26A1
Gene Full Name cytochrome P450, family 26, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Function Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. [UniProt]
Cellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. [UniProt]
Calculated MW 56 kDa