ARG53924
anti-Cytokeratin (pan) antibody [C-11] (APC)
anti-Cytokeratin (pan) antibody [C-11] (APC) for Flow cytometry and Human,Mouse,Rat,Mammal
Signaling Transduction antibody; Carcinoma Marker antibody
Overview
| Product Description | Allophycocyanin-conjugated Mouse Monoclonal antibody [C-11] recognizes Cytokeratin (pan) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Mamm |
| Tested Application | FACS |
| Specificity | The clone C-11 reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C-11 |
| Isotype | IgG1 |
| Target Name | Cytokeratin (pan) |
| Antigen Species | Human |
| Immunogen | Keratin-enriched preparation from human epidermoid carcinoma cell line A431. |
| Conjugation | Allophycocyanin |
| Alternate Names | 67 kDa cytokeratin; KRT1A; EPPK; Keratin, type II cytoskeletal 1; EHK1; K1; Keratin-1; CK1; Cytokeratin-1; Hair alpha protein; Type-II keratin Kb1; CK-1; NEPPK; EHK |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 15 mM Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Concentration | 0.1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KRT1 |
| Gene Full Name | keratin 1, type II |
| Background | Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. |
| Function | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. [UniProt] |
| Research Area | Signaling Transduction antibody; Carcinoma Marker antibody |
| Calculated MW | 66 kDa |
| PTM | Undergoes deimination of some arginine residues (citrullination). |
Clone References
Intracellular distribution of p300 and its differential recruitment to aggresomes in breast cancer.
Establishment and characterization of baboon embryonic stem cell lines: an Old World Primate model for regeneration and transplantation research.
ICC/IF / Baboon
