ARG58482
anti-DDOST antibody
anti-DDOST antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DDOST |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DDOST |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 40-300 of Human DDOST (NP_005207.2). |
| Conjugation | Un-conjugated |
| Alternate Names | Oligosaccharyl transferase 48 kDa subunit; CDG1R; OST48; OKSWcl45; EC 2.4.99.18; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; OST; AGER1; DDOST 48 kDa subunit; WBP1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | U-87MG | ||||||
| Observed Size | 51 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DDOST |
| Gene Full Name | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) |
| Background | This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008] |
| Function | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. [UniProt] |
| Cellular Localization | Endoplasmic reticulum membrane, Single-pass type I membrane protein,. [UniProt] |
| Calculated MW | 51 kDa |
