ARG45064
anti-DISC1 antibody
anti-DISC1 antibody for Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DISC1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DISC1 |
| Antigen Species | Mouse |
| Immunogen | DISC1 synthetic peptide containing amino acid residues from the C-terminus of mouse DISC1. This peptide sequence is well conserved in rat DISC1, but has 7 amino acid differences with the conserved site in human DISC1. |
| Conjugation | Un-conjugated |
| Alternate Names | DISC1; DISC1 Scaffold Protein; Disrupted In Schizophrenia 1 Protein; Disrupted In Schizophrenia 1; C1orf136; KIAA0457; SCZD9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q810H6 Rat Disrupted in schizophrenia 1 homolog Swiss-port # Q811T9 Mouse Disrupted in schizophrenia 1 homolog |
|---|---|
| Gene Symbol | DISC1 |
| Gene Full Name | DISC1 Scaffold Protein |
| Background | This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Function | Plays a role, together with PCNT, in the microtubule network formation. [Uniprot] |
| Cellular Localization | Cytoplasm, Cytoskeleton, Microtubule, Mitochondrion, Synapse. [Uniprot] |
| Calculated MW | 94 kDa |
| PTM | Isopeptide bond, Ubl conjugation. [Uniprot] |
