ARG42391
anti-DLL4 antibody [MHD4-46] (low endotoxin)
anti-DLL4 antibody [MHD4-46] (low endotoxin) for Flow cytometry,Functional study and Human
Overview
| Product Description | Azide free and low endotoxin Mouse Monoclonal antibody [MHD4-46] recognizes DLL4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, FuncSt |
| Specificity | The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MHD4-46 |
| Isotype | IgG1, kappa |
| Target Name | DLL4 |
| Antigen Species | Human |
| Immunogen | Recombinant soluble Human DLL4. |
| Conjugation | Un-conjugated |
| Alternate Names | Drosophila Delta homolog 4; hdelta2; Delta4; Delta-like protein 4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Purification Note | 0.2 µm filter sterilized. Endotoxin level is <0.01 EU/µg of the protein. |
| Buffer | PBS |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DLL4 |
| Gene Full Name | delta-like 4 (Drosophila) |
| Background | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] |
| Function | Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 75 kDa |
