ARG54354
anti-DRAK1 antibody
anti-DRAK1 antibody for ICC/IF,Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DRAK1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Specificity | This antibody recognizes human DRAK1 (50kDa). No cross-reactivity with DRAK2, DAP or ZIP kinases. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DRAK1 |
| Antigen Species | Human |
| Immunogen | Peptide corresponding to aa 5-19 of human DRAK1 (accession no. Q9UEE5). |
| Conjugation | Un-conjugated |
| Alternate Names | EC 2.7.11.1; DRAK1; Serine/threonine-protein kinase 17A; DAP kinase-related apoptosis-inducing protein kinase 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | A431 and MOLT4 |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunoaffinity chroma-tography |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UEE5 Human Serine/threonine-protein kinase 17A |
|---|---|
| Gene Symbol | STK17A |
| Gene Full Name | serine/threonine kinase 17a |
| Background | Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis have been identified and designated DRAK1 and DRAK2 for DAP kinase–related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases which mediate apoptosis through their catalytic activities. DRAK1 is located in cell nuclei, and the mRNA for DRAK1 is ubiquitously expressed in human tissues. |
| Function | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody |
| Calculated MW | 47 kDa |
| PTM | Autophosphorylated. |
