ARG59255
anti-DRAM antibody
anti-DRAM antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DRAM |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DRAM |
| Antigen Species | Human |
| Immunogen | A 16 amino acid synthetic peptide within aa. 30 - 80 of Human DRAM. |
| Conjugation | Un-conjugated |
| Alternate Names | DRAM; Damage-regulated autophagy modulator; DNA damage-regulated autophagy modulator protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | K562 | ||||||
| Observed Size | ~ 30 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8N682 Human DNA damage-regulated autophagy modulator protein 1 Swiss-port # Q9DC58 Mouse DNA damage-regulated autophagy modulator protein 1 |
|---|---|
| Gene Symbol | DRAM1 |
| Gene Full Name | DNA-damage regulated autophagy modulator 1 |
| Background | This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008] |
| Function | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. [UniProt] |
| Cellular Localization | Lysosome membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 26 kDa |
