ARG59255

anti-DRAM antibody

anti-DRAM antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes DRAM
Tested Reactivity Hu, Ms
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name DRAM
Antigen Species Human
Immunogen A 16 amino acid synthetic peptide within aa. 30 - 80 of Human DRAM.
Conjugation Un-conjugated
Alternate Names DRAM; Damage-regulated autophagy modulator; DNA damage-regulated autophagy modulator protein 1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P2 - 20 µg/ml
WB0.5 - 2 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control K562
Observed Size ~ 30 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide.
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 55332 Human DRAM1

GeneID: 71712 Mouse DRAM1

Swiss-port # Q8N682 Human DNA damage-regulated autophagy modulator protein 1

Swiss-port # Q9DC58 Mouse DNA damage-regulated autophagy modulator protein 1

Gene Symbol DRAM1
Gene Full Name DNA-damage regulated autophagy modulator 1
Background This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Function Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. [UniProt]
Cellular Localization Lysosome membrane; Multi-pass membrane protein. [UniProt]
Calculated MW 26 kDa