ARG44814
anti-DRAXIN antibody
anti-DRAXIN antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes DRAXIN |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | DRAXIN |
| Antigen Species | Human |
| Epitope | GALAPGTPAR NLPENHIDLP GPALWTPQAS HHRRRGPGKK EWGPGLPSQA QDGAVVTATR QASRLPEAEG LLPEQSPAGL LQDKDLLLGL ALPYPEKENR PPGWERTRKR SREHKRRRDR LRLHQGRALV RGPSSLMKKA ELSEAQVLDA AMEESSTSLA PTMFFLTTFE AAPATEESLI LPVTSLRPQQ AQPRSDGEVM PTLDMALFDW TDYEDLKPDG WPSAKKKEKH RGKLSSDGNE TSPAEGEPCD HHQDCLPGTC CDLREHLCTP HNRGLNNKCF DDCMCVEGLR CYAKFHRNRR VTRRKGRCVE PETANGDQGS FINV |
| Conjugation | Un-conjugated |
| Alternate Names | DRAXIN; Dorsal Inhibitory Axon Guidance Protein; Neucrin; Dorsal Repulsive Axon Guidance Protein; C1orf187; Neural Tissue-Specific Cysteine-Rich Protein; FLJ34999; Draxin; Chromosome 1 Open Reading Frame 187; AGPA3119; UNQ3119 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | DRAXIN |
|---|---|
| Gene Full Name | Dorsal Inhibitory Axon Guidance Protein |
| Background | Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] |
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. [Uniprot] |
| Cellular Localization | Secreted. [Uniprot] |
| PTM | Glycoprotein. [Uniprot] |
