ARG55202
anti-DRD4 / Dopamine Receptor D4 antibody
anti-DRD4 / Dopamine Receptor D4 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DRD4 / Dopamine Receptor D4 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DRD4 / Dopamine Receptor D4 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human DRD4 (NP_000788.2) |
| Conjugation | Un-conjugated |
| Alternate Names | D4DR; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse liver |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DRD4 |
| Gene Full Name | dopamine receptor D4 |
| Background | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008] |
| Function | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). [UniProt] |
| Research Area | Neuroscience antibody |
| Calculated MW | 44 kDa |
| PTM | Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein. |
