ARG59961
anti-DTX2 / Deltex2 antibody
anti-DTX2 / Deltex2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DTX2 / Deltex2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DTX2 / Deltex2 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-280 of Human DTX2 (NP_065943.2). |
| Conjugation | Un-conjugated |
| Alternate Names | RNF58; EC 6.3.2.-; Probable E3 ubiquitin-protein ligase DTX2; RING finger protein 58; Protein deltex-2; Deltex2; hDTX2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse testis and HepG2 | ||||||
| Observed Size | 67 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q86UW9 Human Probable E3 ubiquitin-protein ligase DTX2 Swiss-port # Q8R3P2 Mouse Probable E3 ubiquitin-protein ligase DTX2 |
|---|---|
| Gene Symbol | DTX2 |
| Gene Full Name | deltex 2, E3 ubiquitin ligase |
| Background | DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
| Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. [UniProt] |
| Cellular Localization | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. [UniProt] |
| Calculated MW | 67 kDa |
