ARG55249
anti-DUX4 antibody [P4H2]
anti-DUX4 antibody [P4H2] for ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Developmental Biology antibody
Overview
| Product Description | Mouse Monoclonal antibody [P4H2] recognizes DUX4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-Fr, IHC-P, WB |
| Specificity | This antibody recognizes an epitope at the C-terminus of human DUX4. It does not cross-react with DUX4c. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | P4H2 |
| Isotype | IgG1 |
| Target Name | DUX4 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around 76 aa (C-terminus) of Human DUX4 with GST tag. |
| Conjugation | Un-conjugated |
| Alternate Names | Double homeobox protein 10; Double homeobox protein 4; DUX4L |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Positive Control | Human testis lysate. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4). |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DUX4 |
| Gene Full Name | double homeobox 4 |
| Background | This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| Function | Involved in transcriptional regulation. May regulate microRNA (miRNA) expression. [UniProt] |
| Research Area | Developmental Biology antibody |
| Calculated MW | 45 kDa |
