ARG54847
anti-DYRK1B antibody
anti-DYRK1B antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cancer antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DYRK1B |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DYRK1B |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 561-589 (C-terminus) of Human DYRK1B. |
| Conjugation | Un-conjugated |
| Alternate Names | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; MIRK; Minibrain-related kinase; EC 2.7.12.1; AOMS3; Mirk protein kinase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse kidney |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y463 Human Dual specificity tyrosine-phosphorylation-regulated kinase 1B Swiss-port # Q9Z188 Mouse Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|---|
| Gene Symbol | DYRK1B |
| Gene Full Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B |
| Background | This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). [UniProt] |
| Cellular Localization | Nucleus. |
| Research Area | Cancer antibody |
| Calculated MW | 69 kDa |
| PTM | Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. |
