ARG65661
anti-Dengue virus NS1 antibody [SQab1502]
anti-Dengue virus NS1 antibody [SQab1502] for ELISA,ICC/IF and Dengue virus
Microbiology and Infectious Disease antibody
Overview
| Product Description | Mouse Monoclonal antibody [SQab1502] recognizes Dengue virus NS1 |
|---|---|
| Tested Reactivity | DEN |
| Tested Application | ELISA, ICC/IF |
| Specificity | This antibody recognizes monomer, dimer, hexamer of DENV1/2/3/4 NS1 protein. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SQab1502 |
| Isotype | IgG |
| Target Name | Dengue virus NS1 |
| Antigen Species | Virus |
| Immunogen | Recombinant hexamer Dengue virus NS1 protein from drosophila cell |
| Conjugation | Un-conjugated |
| Alternate Names | Dengue virus NS1 antibody; Dengue virus nonstructural glycoprotein NS1 antibody |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | Recommend using ARG65660 Dengue virus NS1 antibody [SQab1501] for WB, ICC/IF and flow cytrometry studies. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS (pH 7.4) and 0.01% Thimerosal. |
| Preservative | 0.01% Thimerosal |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | DENV_gp1 |
|---|---|
| Gene Full Name | Dengue virus nonstructural protein 1 |
| Background | Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients' blood samples (up to 50 μg/mL) or infected cell supernatants (various from ng/mL to μg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic. |
| Function | Dengue virus (DENV) non-structural protein 1 (NS1) is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome. [Uniprot] |
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| Research Area | Microbiology and Infectious Disease antibody |
