ARG40615

anti-Desmocollin 1 antibody

anti-Desmocollin 1 antibody for Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes Desmocollin 1
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Desmocollin 1
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 480-690 of Human Desmocollin 1 (NP_077739.1).
Conjugation Un-conjugated
Alternate Names DG2/DG3; Desmocollin-1; CDHF1; Desmosomal glycoprotein 2/3; Cadherin family member 1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Raji
Observed Size 105 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 13505 Mouse DSC1

GeneID: 1823 Human DSC1

Swiss-port # P55849 Mouse Desmocollin-1

Swiss-port # Q08554 Human Desmocollin-1

Gene Symbol DSC1
Gene Full Name desmocollin 1
Background The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. [UniProt]
Cellular Localization Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. [UniProt]
Calculated MW 100 kDa