ARG58500

anti-Desmocollin 2 antibody

anti-Desmocollin 2 antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes Desmocollin 2
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Desmocollin 2
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 520-690 of Human Desmocollin 2 (NP_077740.1).
Conjugation Un-conjugated
Alternate Names Desmosomal glycoprotein II; ARVD11; Desmosomal glycoprotein III; DSC3; Desmocollin-3; Desmocollin-2; DG2; CDHF2; DGII/III; Cadherin family member 2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control BT474
Observed Size 105 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1824 Human DSC2

Swiss-port # Q02487 Human Desmocollin-2

Gene Symbol DSC2
Gene Full Name desmocollin 2
Background This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [UniProt]
Cellular Localization Cell membrane, Single-pass type I membrane protein, Cell junction, desmosome. [UniProt]
Calculated MW 100 kDa