ARG58500
anti-Desmocollin 2 antibody
anti-Desmocollin 2 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Desmocollin 2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Desmocollin 2 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 520-690 of Human Desmocollin 2 (NP_077740.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Desmosomal glycoprotein II; ARVD11; Desmosomal glycoprotein III; DSC3; Desmocollin-3; Desmocollin-2; DG2; CDHF2; DGII/III; Cadherin family member 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | BT474 | ||||
| Observed Size | 105 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DSC2 |
| Gene Full Name | desmocollin 2 |
| Background | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [UniProt] |
| Cellular Localization | Cell membrane, Single-pass type I membrane protein, Cell junction, desmosome. [UniProt] |
| Calculated MW | 100 kDa |
