ARG42733

anti-Desmocollin 3 antibody

anti-Desmocollin 3 antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes Desmocollin 3
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Desmocollin 3
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide between aa. 822-850 of Human Desmocollin 3.
Conjugation Un-conjugated
Alternate Names Desmocollin-4; DSC4; DSC2; Cadherin family member 3; Desmocollin-3; DSC; CDHF3; DSC1; HT-CP

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control A431
Observed Size ~ 95 kDa

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1825 Human DSC3

Swiss-port # Q14574 Human Desmocollin-3

Gene Symbol DSC3
Gene Full Name desmocollin 3
Background The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [UniProt]
Cellular Localization Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. [UniProt]
Calculated MW 100 kDa