ARG52262
anti-Dopamine beta Hydroxylase antibody
anti-Dopamine beta Hydroxylase antibody for Western blot and Human,Primates
Cancer antibody; Metabolism antibody; Neuroscience antibody
Overview
| Product Description | Sheep Polyclonal antibody recognizes Dopamine beta Hydroxylase |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | WB |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Dopamine beta Hydroxylase |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | EC 1.14.17.1; DBM; Dopamine beta-monooxygenase; Dopamine beta-hydroxylase |
Application Instructions
| Application Suggestion |
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| Application Note | Specific for the ~75k DBH protein in Western blots * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DBH |
| Gene Full Name | dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| Background | DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). The expression of DBH is also elevated during stress (Sabban and Kvetnansky, 2001). |
| Research Area | Cancer antibody; Metabolism antibody; Neuroscience antibody |
| Calculated MW | 69 kDa |
| PTM | N-glycosylated. Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. |
