ARG44653
anti-Dynamin antibody
anti-Dynamin antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human,Mouse
Overview
| Product Description | Mouse Monoclonal antibody recognizes Dynamin |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | Dynamin |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | DNM1; Dynamin 1; DNM; EC 3.6.5.5; Dynamin-1; Dynamin I; Dynamin; DEE31A; DEE31B; EIEE31; DEE31 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Dynamin 1 |
| Gene Full Name | DNM1 |
| Background | This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| Function | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation. [UniProt] |
| Cellular Localization | Cell membrane, Cell projection, Coated pit, Cytoplasmic vesicle, Membrane, Microtubule, Synapse. [UniProt] |
| Calculated MW | 97 kDa |
| PTM | Methylation, Nitration, Phosphoprotein. [UniProt] |
