ARG10566
anti-EBV LMP1 antibody [D24-G]
anti-EBV LMP1 antibody [D24-G] for IHC-Formalin-fixed paraffin-embedded sections and EBV
Overview
| Product Description | Rabbit Monoclonal antibody [D24-G] recognizes EBV LMP1 |
|---|---|
| Tested Reactivity | EBV |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | D24-G |
| Isotype | IgG |
| Target Name | EBV LMP1 |
| Antigen Species | Virus |
| Immunogen | Synthetic peptide around the internal region of EBV's Latent Membrane Protein-1 |
| Conjugation | Un-conjugated |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 20 mg/ml BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | LMP1 |
|---|---|
| Gene Full Name | LMP1 |
| Function | Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. [UniProt] |
