ARG42138
anti-ECSM2 antibody
anti-ECSM2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Goat Polyclonal antibody recognizes ECSM2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ECSM2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the C-terminus of Human ECSM2. (C-NNGKQSLSAEKVL) (NP_001071161.1) |
| Conjugation | Un-conjugated |
| Alternate Names | Apoptosis regulator through modulating IAP expression; ARIA; Endothelial cell-specific molecule 2; Endothelial cell-specific chemotaxis regulator; ECSM2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Human lung and Human umbilical cord. | ||||||
| Observed Size | ~ 50 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q19T08 Human Endothelial cell-specific chemotaxis regulator |
|---|---|
| Gene Symbol | ECSCR |
| Gene Full Name | endothelial cell surface expressed chemotaxis and apoptosis regulator |
| Background | The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| Function | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Cytoplasm. [UniProt] |
| Calculated MW | 21 kDa |
| PTM | May be heavily O-glycosylated. [UniProt] |
