ARG44817
anti-EDA2R / XEDAR antibody
anti-EDA2R / XEDAR antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes EDA2R / XEDAR |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | EDA2R / XEDAR |
| Antigen Species | Human |
| Epitope | DKTAKEESLF PVPPSKETSA ESQVSENIFQ TQPLNPILED DCSSTSGFPT QESFTMASCT SESHSHWVHS |
| Conjugation | Un-conjugated |
| Alternate Names | EDA2R; Ectodysplasin A2 Receptor; TNFRSF27; XEDAR; EDA-A2R; EDAA2R; Tumor Necrosis Factor Receptor Superfamily Member 27; X-Linked Ectodysplasin-A2 Receptor; X-Linked EDA Receptor; EDA-A2 Receptor; Tumor Necrosis Factor Receptor Superfamily Member XEDAR |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | EDA2R |
|---|---|
| Gene Full Name | Ectodysplasin A2 Receptor |
| Background | The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016] |
| Function | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. [Uniprot] |
| Cellular Localization | Membrane. [Uniprot] |
| PTM | Disulfide bond, Glycoprotein. [Uniprot] |
