ARG58674
anti-EHHADH antibody
anti-EHHADH antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Rat
Overview
Product Description | Rabbit Polyclonal antibody recognizes EHHADH |
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Tested Reactivity | Hu, Rat |
Tested Application | ICC/IF, IHC-P |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | EHHADH |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 444-723 of Human EHHADH (NP_001957.2). |
Conjugation | Un-conjugated |
Alternate Names | LBP; ECHD; LBFP; L-PBE; PBE; PBFE; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; FRTS3; Peroxisomal bifunctional enzyme |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Observed Size | 79 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | EHHADH |
Gene Full Name | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase |
Background | The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
Cellular Localization | Peroxisome. [UniProt] |
Calculated MW | 79 kDa |
PTM | Acetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with highest increase on Lys-346. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids. [UniProt] |