ARG43031
anti-EML4 antibody
anti-EML4 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes EML4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | EML4 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 360-560 of Human EML4 (NP_061936.2). |
| Conjugation | Un-conjugated |
| Alternate Names | ELP120; ROPP120; C2orf2; Echinoderm microtubule-associated protein-like 4; EMAP-4; Ropp 120; EMAPL4; Restrictedly overexpressed proliferation-associated protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q3UMY5 Mouse Echinoderm microtubule-associated protein-like 4 Swiss-port # Q9HC35 Human Echinoderm microtubule-associated protein-like 4 |
|---|---|
| Gene Symbol | EML4 |
| Gene Full Name | echinoderm microtubule associated protein like 4 |
| Background | This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015] |
| Function | May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. [UniProt] |
| Cellular Localization | Cytoplasm, cytoskeleton. [UniProt] |
| Calculated MW | 109 kDa |
