ARG55026
anti-FACE1 / ZMPSTE24 antibody
anti-FACE1 / ZMPSTE24 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FACE1 / ZMPSTE24 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FACE1 / ZMPSTE24 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 400-430 (Center) of Human ZMPSTE24. |
| Conjugation | Un-conjugated |
| Alternate Names | CAAX prenyl protease 1 homolog; EC 3.4.24.84; STE24; Ste24p; HGPS; FACE-1; Farnesylated proteins-converting enzyme 1; FACE1; Prenyl protein-specific endoprotease 1; PRO1; Zinc metalloproteinase Ste24 homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse cerebellum |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ZMPSTE24 |
| Gene Full Name | zinc metallopeptidase STE24 |
| Background | This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008] |
| Function | Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. [UniProt] |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein |
| Research Area | Cell Biology and Cellular Response antibody; Developmental Biology antibody; Signaling Transduction antibody |
| Calculated MW | 55 kDa |
