ARG57146

anti-FH / Fumarase antibody [3F6]

anti-FH / Fumarase antibody [3F6] for Western blot,Flow cytometry,ICC/IF and Human

Overview

Product Description Mouse Monoclonal antibody [3F6] recognizes FH / Fumarase
Tested Reactivity Hu
Tested Application FACS, ICC/IF, WB
Host Mouse
Clonality Monoclonal
Clone 3F6
Isotype IgG2a, kappa
Target Name FH / Fumarase
Antigen Species Human
Immunogen Recombinant fragment around aa. 44-510 of Human FH / Fumarase
Conjugation Un-conjugated
Alternate Names MCUL1; MCL; LRCC; EC 4.2.1.2; Fumarate hydratase, mitochondrial; FMRD; Fumarase; HLRCC

Application Instructions

Application Suggestion
Tested Application Dilution
FACSAssay-dependent
ICC/IFAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 10% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 2271 Human FH

Swiss-port # P07954 Human Fumarate hydratase, mitochondrial

Gene Symbol FH
Gene Full Name fumarate hydratase
Background The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]
Function Also acts as a tumor suppressor. [UniProt]
Highlight Related products:
Fumarase antibodies; Fumarase ELISA Kits; Anti-Mouse IgG secondary antibodies;
Related news:
TCA intermediate fumarate promotes mitobiogenesis
Calculated MW 55 kDa