ARG45067
anti-FHOD1 antibody [M352]
anti-FHOD1 antibody [M352] for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [M352] recognizes FHOD1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | M352 |
| Isotype | IgG1 |
| Target Name | FHOD1 |
| Antigen Species | Human |
| Immunogen | FHOD1 recombinant protein that included the full length human FHOD1 sequence. This sequence has 50% homology to human FHOD3, and low homology to other formin family members. |
| Conjugation | Un-conjugated |
| Alternate Names | FHOD1; Formin Homology 2 Domain Containing 1; FHOS; Formin Homolog Overexpressed In Spleen 1; FH1/FH2 Domain-Containing Protein 1; Formin Homology 2 Domain-Containing Protein 1; FHOS1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y613 Human FH1/FH2 domain-containing protein 1 |
|---|---|
| Gene Symbol | FHOD1 |
| Gene Full Name | Formin Homology 2 Domain Containing 1 |
| Background | This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| Function | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. [Uniprot] |
| Cellular Localization | Cell projection, Cytoplasm, Cytoskeleton. [Uniprot] |
| Calculated MW | 127 kDa |
| PTM | Phosphoprotein. [Uniprot] |
