ARG44664
anti-FKBP51 antibody
anti-FKBP51 antibody for Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes FKBP51 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | FKBP51 |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | FKBP5; FKBP Prolyl Isomerase 5; FKBP51; FKBP54; P54; PPIase; Ptg-10; 54 KDa Progesterone Receptor-Associated Immunophilin; Peptidyl-Prolyl Cis-Trans Isomerase FKBP5; 51 KDa FK506-Binding Protein; Androgen-Regulated Protein 6; HSP90-Binding Immunophilin; FK506-Binding Protein 5; FK506 Binding Protein 5; PPIase FKBP5; 51 KDa FKBP; FF1 Antigen; EC 5.2.1.8; Rotamase; FKBP-51; AIG6; Peptidylprolyl Cis-Trans Isomerase; T-Cell FK506-Binding Protein; FKBP-5 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13451 Human Peptidyl-prolyl cis-trans isomerase FKBP5 |
|---|---|
| Gene Symbol | FKBP5 |
| Gene Full Name | FKBP Prolyl Isomerase 5 |
| Background | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| Function | Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus. [UniProt] |
| Calculated MW | 51 kDa |
| PTM | Acetylation, Phosphoprotein, Ubl conjugation. [UniProt] |
