ARG45097
anti-FKLF / KLF11 antibody
anti-FKLF / KLF11 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FKLF / KLF11 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FKLF / KLF11 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to amino acids from the N-terminal region of human FKLF protein |
| Conjugation | Un-conjugated |
| Alternate Names | KLF11; KLF Transcription Factor 11; FKLF; Tieg3; MODY7; TIEG2; Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 2; TGFB-Inducible Early Growth Response Protein 2; Krueppel-Like Factor 11; Kruppel Like Factor 11; TIEG-2; TGFB Inducible Early Growth Response 2; FKLF1 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.02% NaN3 |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KLF11 |
| Gene Full Name | KLF Transcription Factor 11 |
| Background | The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] |
| Function | Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. [Uniprot] |
| Cellular Localization | Nucleus. [Uniprot] |
| Calculated MW | 55 kDa |
| PTM | Phosphoprotein. [Uniprot] |
