ARG58793

anti-FNDC5 antibody

anti-FNDC5 antibody for Western blot and Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes FNDC5
Tested Reactivity Ms, Rat
Predict Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name FNDC5
Antigen Species Human
Immunogen Recombinant protein corresponding to D32-E143 of Human FNDC5.
Conjugation Un-conjugated
Alternate Names irisin; FRCP2; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.1 - 0.5 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose.
Preservative 0.05% Sodium azide
Stabilizer 4% Trehalose
Concentration 0.5 - 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 260327 Rat FNDC5

GeneID: 384061 Mouse FNDC5

Swiss-port # Q8K3V5 Rat Fibronectin type III domain-containing protein 5

Swiss-port # Q8K4Z2 Mouse Fibronectin type III domain-containing protein 5

Gene Symbol FNDC5
Gene Full Name fibronectin type III domain containing 5
Background This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Function Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. [UniProt]
Cellular Localization Cell membrane. [UniProt]
Calculated MW 23 kDa
PTM The extracellular domain is cleaved and released from the cell membrane.

N-Glycosylated. [UniProt]