ARG54091
anti-FYB antibody
anti-FYB antibody for Western blot and Human
Controls and Markers antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes FYB |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | FYB |
| Antigen Species | Human |
| Immunogen | Purified recombinant human FYB protein fragments expressed in E.coli. |
| Conjugation | Un-conjugated |
| Alternate Names | FYN-binding protein; FYN-T-binding protein; ADAP; FYB-120/130; SLAP130; SLP-76-associated phosphoprotein; SLAP-130; p120/p130; Adhesion and degranulation promoting adaptor protein; PRO0823 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | 120 kDa |
Properties
| Form | Liquid |
|---|---|
| Buffer | Ascites containing with 0.02% Sodium azide and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FYB |
| Gene Full Name | FYN binding protein |
| Background | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells.Modulates the expression of interleukin-2 (IL-2).Involved in platelet activation.Prevents the degradation of SKAP1 and SKAP2.May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. [UniProt] |
| Cellular Localization | Cytoplasm. Nucleus |
| Research Area | Controls and Markers antibody; Signaling Transduction antibody |
| Calculated MW | 85 kDa |
| PTM | T-cell receptor ligation leads to increased tyrosine phosphorylation. |
