ARG55823
anti-Fxyd 1 antibody
anti-Fxyd 1 antibody for Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Fxyd 1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Fxyd 1 |
| Antigen Species | Mouse |
| Immunogen | KLH-conjugated synthetic peptide around the N-terminal region of Mouse Fxyd 1. |
| Conjugation | Un-conjugated |
| Alternate Names | FXYD domain-containing ion transport regulator 1; Phospholemman; 0610012C17Rik; 1110006M24Rik; Pml; Plm |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Rat heart |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Fxyd1 |
| Gene Full Name | FXYD domain-containing ion transport regulator 1 |
| Background | This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009] |
| Function | May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed (By similarity). [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Calculated MW | 10 kDa |
| PTM | Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA. |
