ARG42287
anti-G-CSF Receptor antibody [LMM741] (PE)
anti-G-CSF Receptor antibody [LMM741] (PE) for Flow cytometry and Human
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [LMM741] recognizes G-CSF Receptor |
|---|---|
| Tested Reactivity | Hu |
| Species Does Not React With | Ms |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody LMM741 recognizes an extracellular epitope of CD114 (colony stimulating factor 3 receptor), a 130 kDa transmembrane glycoprotein expressed on granulocytes and their differentiation stages, on monocytes, platelets, endothelial cells and placenta. It is absent from lymphocytes and erythrocytes. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | LMM741 |
| Isotype | IgG1, kappa |
| Target Name | G-CSF Receptor |
| Antigen Species | Human |
| Immunogen | CHO cells transfected with Human CD114. |
| Conjugation | PE |
| Alternate Names | G-CSF receptor; CD114; CD antigen CD114; G-CSF-R; GCSFR; Granulocyte colony-stimulating factor receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q99062 Human Granulocyte colony-stimulating factor receptor |
|---|---|
| Gene Symbol | CSF3R |
| Gene Full Name | colony stimulating factor 3 receptor (granulocyte) |
| Background | The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010] |
| Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. [UniProt] |
| Cellular Localization | Isoform 2: Secreted. Cell membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 92 kDa |
| PTM | N-glycosylated. [UniProt] |
