ARG10017
anti-G-CSF Receptor antibody [S-1284]
anti-G-CSF Receptor antibody [S-1284] for Western blot and Human
Cancer antibody; Developmental Biology antibody; Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [S-1284] recognizes G-CSF Receptor |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S-1284 |
| Isotype | IgG2a, kappa |
| Target Name | G-CSF Receptor |
| Antigen Species | Human |
| Immunogen | Purified recombinant MBP-GCSFR fusion protein |
| Conjugation | Un-conjugated |
| Alternate Names | G-CSF receptor; CD114; CD antigen CD114; G-CSF-R; GCSFR; Granulocyte colony-stimulating factor receptor |
Application Instructions
| Application Note | Western Blot: The antibody, when used at concentration of 1-10μg/mL will allow visualization of 250 ng/lane of human G-CSFR-MBP. The antibody recognizes denatured G-CSFR in Western blot following SDS-PAGE. Suggest use 200μg of cell lysate or immunoprecipitated protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G affinity purified |
| Buffer | 0.01M PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q99062 Human Granulocyte colony-stimulating factor receptor |
|---|---|
| Gene Symbol | CSF3R |
| Gene Full Name | colony stimulating factor 3 receptor (granulocyte) |
| Background | The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010] |
| Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. [UniProt] |
| Research Area | Cancer antibody; Developmental Biology antibody; Immune System antibody |
| Calculated MW | 92 kDa |
| PTM | N-glycosylated. |
Clone References
Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor.
IHC / Human
