ARG10716
anti-GAP43 antibody [5E8]
anti-GAP43 antibody [5E8] for ICC/IF,IHC-Frozen sections,Western blot and Human,Mouse,Rat
Overview
Product Description | Mouse Monoclonal antibody [5E8] recognizes GAP43 |
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Tested Reactivity | Hu, Ms, Rat |
Tested Application | ICC/IF, IHC-Fr, WB |
Host | Mouse |
Clonality | Monoclonal |
Clone | 5E8 |
Isotype | IgG1 |
Target Name | GAP43 |
Antigen Species | Human |
Immunogen | Recombinant full-length Human GAP43. |
Conjugation | Un-conjugated |
Alternate Names | pp46; Growth-associated protein 43; B-50; Neuromodulin; PP46; Axonal membrane protein GAP-43; Neural phosphoprotein B-50 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Affinity purification. |
Buffer | PBS and 50% Glycerol. |
Stabilizer | 50% Glycerol |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | GAP43 |
Gene Full Name | growth associated protein 43 |
Background | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Function | This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. [UniProt] |
Calculated MW | 25 kDa |
PTM | Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2. |