ARG59635
anti-GCNT1 antibody
anti-GCNT1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes GCNT1 |
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Tested Reactivity | Hu |
Tested Application | IHC-P |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | GCNT1 |
Antigen Species | Human |
Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 88-117 of Human GCNT1. |
Conjugation | Un-conjugated |
Alternate Names | NAGCT2; Core 2 GNT; G6NT; C2GNT1; Core 2-branching enzyme; Core2-GlcNAc-transferase; NACGT2; C2GNT; EC 2.4.1.102; C2GNT-L; Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purification with Protein G. |
Buffer | PBS and 0.09% (W/V) Sodium azide. |
Preservative | 0.09% (W/V) Sodium azide |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q02742 Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminylt |
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Gene Symbol | GCNT1 |
Gene Full Name | glucosaminyl (N-acetyl) transferase 1, core 2 |
Background | This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
Function | Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. [UniProt] |
Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein. Note=Also detected in the trans-Golgi network. [UniProt] |
Calculated MW | 50 kDa |