ARG55391
anti-GHSR / Ghrelin Receptor antibody
anti-GHSR / Ghrelin Receptor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Metabolism antibody; Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GHSR / Ghrelin Receptor |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Pig, Rb |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GHSR / Ghrelin Receptor |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 326-357 (C-terminus) of Human GHSR. |
| Conjugation | Un-conjugated |
| Alternate Names | GHDP; Growth hormone secretagogue receptor type 1; GHS-R; GH-releasing peptide receptor; GHRP; Ghrelin receptor |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse bladder |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q92847 Human Growth hormone secretagogue receptor type 1 Swiss-port # Q99P50 Mouse Growth hormone secretagogue receptor type 1 |
|---|---|
| Gene Symbol | GHSR |
| Gene Full Name | growth hormone secretagogue receptor |
| Background | This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010] |
| Function | Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Research Area | Metabolism antibody; Neuroscience antibody |
| Calculated MW | 41 kDa |
