ARG59586
anti-GIF / Gastric intrinsic factor antibody
anti-GIF / Gastric intrinsic factor antibody for ICC/IF and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GIF / Gastric intrinsic factor |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GIF / Gastric intrinsic factor |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 20-300 of Human GIF (NP_005133.2). |
| Conjugation | Un-conjugated |
| Alternate Names | Gastric intrinsic factor; IFMH; TCN3; Intrinsic factor; INF; IF |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse pancreas |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GIF |
| Gene Full Name | gastric intrinsic factor (vitamin B synthesis) |
| Background | This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008] |
| Function | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 45 kDa |
