ARG66400

anti-GIPR antibody

anti-GIPR antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes GIPR
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name GIPR
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 60-140 of Human GIPR.
Conjugation Un-conjugated
Alternate Names PGQTL2; GIP-R; Glucose-dependent insulinotropic polypeptide receptor; Gastric inhibitory polypeptide receptor

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size ~ 53 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.5% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 2696 Human GIPR

Swiss-port # P48546 Human Gastric inhibitory polypeptide receptor

Gene Symbol GIPR
Gene Full Name gastric inhibitory polypeptide receptor
Background This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Function This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. [UniProt]
Cellular Localization Cell membrane; Multi-pass membrane protein. [UniProt]
Calculated MW 53 kDa
PTM N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER. [UniProt]