ARG57070
anti-GPD1L antibody [14E2]
anti-GPD1L antibody [14E2] for Western blot and Human
Overview
Product Description | Mouse Monoclonal antibody [14E2] recognizes GPD1L |
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Tested Reactivity | Hu |
Tested Application | WB |
Host | Mouse |
Clonality | Monoclonal |
Clone | 14E2 |
Isotype | IgG1, kappa |
Target Name | GPD1L |
Antigen Species | Human |
Immunogen | Recombinant fragment around aa. 1-351 of Human GPD1L. |
Conjugation | Un-conjugated |
Alternate Names | Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; EC 1.1.1.8 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purification with Protein A. |
Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 10% Glycerol |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q8N335 Human Glycerol-3-phosphate dehydrogenase 1-like protein |
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Gene Symbol | GPD1L |
Gene Full Name | glycerol-3-phosphate dehydrogenase 1-like |
Background | The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010] |
Function | Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. [UniProt] |
Calculated MW | 38 kDa |