ARG57070

anti-GPD1L antibody [14E2]

anti-GPD1L antibody [14E2] for Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [14E2] recognizes GPD1L
Tested Reactivity Hu
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 14E2
Isotype IgG1, kappa
Target Name GPD1L
Antigen Species Human
Immunogen Recombinant fragment around aa. 1-351 of Human GPD1L.
Conjugation Un-conjugated
Alternate Names Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; EC 1.1.1.8

Application Instructions

Application Suggestion
Tested Application Dilution
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 10% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 23171 Human GPD1L

Swiss-port # Q8N335 Human Glycerol-3-phosphate dehydrogenase 1-like protein

Gene Symbol GPD1L
Gene Full Name glycerol-3-phosphate dehydrogenase 1-like
Background The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
Function Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. [UniProt]
Calculated MW 38 kDa