ARG44591
anti-GPR77 / C5L2 antibody [1D9-M12] (APC)
anti-GPR77 / C5L2 antibody [1D9-M12] (APC) for Flow cytometry and Human
Overview
| Product Description | APC-conjugated Mouse Monoclonal antibody recognizes GPR77 / C5L2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1D9-M12 |
| Isotype | IgG2a kappa |
| Target Name | GPR77 / C5L2 |
| Antigen Species | Human |
| Conjugation | APC |
| Alternate Names | C5AR2; Complement C5a Receptor 2; C5L2; Complement Component 5a Receptor 2; GPR77; C5a Anaphylatoxin Chemotactic Receptor 2; G Protein-Coupled Receptor 77; C5a Anaphylatoxin Chemotactic Receptor C5L2; G Protein-Coupled Receptor C5L2; G-Protein Coupled Receptor 77; GPF77 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified antibody is conjugated with activated allophycocyanin (APC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9P296 Human C5a anaphylatoxin chemotactic receptor 2 |
|---|---|
| Gene Symbol | C5AR2 |
| Gene Full Name | complement component 5a receptor 2 |
| Background | This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
| Function | Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. [UniProt] |
| Cellular Localization | Cell membrane, Membrane. [UniProt] |
| Calculated MW | 36 kDa |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
