ARG45094
anti-GRC5 / PHF2 antibody
anti-GRC5 / PHF2 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GRC5 / PHF2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GRC5 / PHF2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to residues from an internal region of the 120 kDa PHF protein |
| Conjugation | Un-conjugated |
| Alternate Names | PHF2; PHD Finger Protein 2; CENP-35; KIAA0662; JHDM1E; KDM7C; Jumonji C Domain-Containing Histone Demethylase 1E; Lysine-Specific Demethylase PHF2; Centromere Protein 35; GRC5; EC 1.14.11.- |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.02% NaN3 |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PHF2 |
| Gene Full Name | PHD Finger Protein 2 |
| Background | This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008] |
| Function | Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters. [Uniprot] |
| Cellular Localization | Centromere, Chromosome, Kinetochore, Nucleus. [Uniprot] |
| Calculated MW | 121 kDa |
| PTM | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
