ARG55272

anti-GRIK1 / GluR5 antibody

anti-GRIK1 / GluR5 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Neuroscience antibody
publication_link Publication1

Overview

Product Description Rabbit Polyclonal antibody recognizes GRIK1 / GluR5
Tested Reactivity Hu, Ms
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name GRIK1 / GluR5
Antigen Species Human
Immunogen Synthetic peptide (15 aa) within the last 50 aa of Human GRIK1 / GluR5.
Conjugation Un-conjugated
Alternate Names GluR5; GluK1; GLUR5; EEA3; GluR-5; Excitatory amino acid receptor 3; Glutamate receptor ionotropic, kainate 1; EAA3; Glutamate receptor 5; GLR5

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P2.5 μg/ml
WB0.5 - 2 μg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control P815 Cell Lysate

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 2897 Human GRIK1

Swiss-port # P39086 Human Glutamate receptor ionotropic, kainate 1

Gene Symbol GRIK1
Gene Full Name glutamate receptor, ionotropic, kainate 1
Background Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. [UniProt]
Research Area Neuroscience antibody
Calculated MW 104 kDa

Specific References

Ultrarare Loss-of-Function Mutations in the Genes Encoding the Ionotropic Glutamate Receptors of Kainate Subtypes Associated with Schizophrenia Disrupt the Interaction with PSD95

WB / Huaman

Tsung-Ming Hu et al.
Personalized Medicine,  (2022)

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