ARG59606
anti-GUCY2F antibody
anti-GUCY2F antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GUCY2F |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GUCY2F |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 250-460 of Human GUCY2F (NP_001513.2). |
| Conjugation | Un-conjugated |
| Alternate Names | ROS-GC2; CYGF; Rod outer segment membrane guanylate cyclase 2; Guanylate cyclase F; Retinal guanylyl cyclase 2; GC-F; GUC2F; GUC2DL; EC 4.6.1.2; RETGC-2; Guanylate cyclase 2F, retinal |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse eye | ||||
| Observed Size | 125 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GUCY2F |
| Gene Full Name | guanylate cyclase 2F, retinal |
| Background | The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008] |
| Function | Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 125 kDa |
| PTM | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. [UniProt] |
