ARG43594
anti-Glutathione Reductase antibody
anti-Glutathione Reductase antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Glutathione Reductase |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Glutathione Reductase |
| Antigen Species | Human |
| Immunogen | Synthetic peptide within a.a. 380-408 from the C-terminal region of human Glutathione Reductase. |
| Conjugation | Un-conjugated |
| Protein Full Name | Glutathione reductase, mitochondrial |
| Alternate Names | GRase; HEL-75; EC 1.8.1.7; Glutathione reductase, mitochondrial; GR |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Heat mediation antigen retrieval is needed. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Observed Size | ~ 55 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P00390 Human Glutathione reductase, mitochondrial |
|---|---|
| Gene Symbol | GSR |
| Gene Full Name | glutathione reductase |
| Background | This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010] |
| Function | Maintains high levels of reduced glutathione in the cytosol. [UniProt] |
| Cellular Localization | Cytoplasm, Mitochondrion |
| Calculated MW | 56 kDa |
| PTM | Acetylation, Disulfide bond |
