ARG62498
anti-GnRHR / GnRH Receptor antibody [B470]
anti-GnRHR / GnRH Receptor antibody [B470] for IHC-Frozen sections and Human
Neuroscience antibody
Overview
| Product Description | Mouse Monoclonal antibody [B470] recognizes GnRHR / GnRH Receptor |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-Fr |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B470 |
| Isotype | IgG1 |
| Target Name | GnRHR / GnRH Receptor |
| Antigen Species | Human |
| Immunogen | BSA-conjugated peptide corresponding to aa. 1-29 (extracellular domain) of Human GnRHR. |
| Conjugation | Un-conjugated |
| Alternate Names | GRHR; HH7; LRHR; LHRHR; Gonadotropin-releasing hormone receptor; GnRH receptor; GNRHR1; GnRH-R |
Application Instructions
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A affinity purified |
| Buffer | PBS (pH 7.2), 0.1% BSA and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 0.1% BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P30968 Human Gonadotropin-releasing hormone receptor |
|---|---|
| Gene Symbol | GNRHR |
| Gene Full Name | gonadotropin-releasing hormone receptor |
| Background | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Function | Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. [UniProt] |
| Research Area | Neuroscience antibody |
| Calculated MW | 38 kDa |
