ARG10785
anti-Guanylate Cyclase C antibody
anti-Guanylate Cyclase C antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Guanylate Cyclase C |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | Confocal, Dot, ELISA, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Guanylate Cyclase C |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide around the C-terminus from Rat Guanylyl cyclase C. |
| Conjugation | Un-conjugated |
| Alternate Names | MECIL; STAR; STA receptor; MUCIL; hSTAR; Heat-stable enterotoxin receptor; Intestinal guanylate cyclase; Guanylyl cyclase C; GUC2C; EC 4.6.1.2; DIAR6; GC-C |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.65 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Gucy2c |
| Gene Full Name | guanylate cyclase 2C |
| Function | Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. [UniProt] |
| Calculated MW | 123 kDa |
| PTM | Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation. |
