ARG44495
anti-HAAO antibody
anti-HAAO antibody for ICC/IF,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HAAO |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HAAO |
| Antigen Species | Human |
| Immunogen | Human HAAO recombinant protein |
| Conjugation | Un-conjugated |
| Alternate Names | HAAO; 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-HAO; 3-Hydroxyanthranilic Acid Dioxygenase; 3-Hydroxyanthranilate Oxygenase; EC 1.13.11.6; H3HAO; HAO; HAD; 3-Hydroxyanthranilic-Acid Dioxygenase; VCRL1 |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # P46952 Human 3-hydroxyanthranilate 3,4-dioxygenase Swiss-port # P46953 Rat 3-hydroxyanthranilate 3,4-dioxygenase |
|---|---|
| Gene Symbol | HAAO |
| Gene Full Name | 3-Hydroxyanthranilate 3,4-Dioxygenase |
| Background | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. |
| Function | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Cellular Localization | Cytoplasm |
| Calculated MW | 33 kDa |
