ARG57756
anti-HCLS1 antibody
anti-HCLS1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HCLS1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HCLS1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-280 of Human HCLS1 (NP_005326.2). |
| Conjugation | Un-conjugated |
| Alternate Names | p75; LckBP1; Hematopoietic cell-specific LYN substrate 1; HS1; Hematopoietic lineage cell-specific protein; CTTNL; lckBP1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Jurkat |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P14317 Human Hematopoietic lineage cell-specific protein Swiss-port # P49710 Mouse Hematopoietic lineage cell-specific protein |
|---|---|
| Gene Symbol | HCLS1 |
| Gene Full Name | hematopoietic cell-specific Lyn substrate 1 |
| Function | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. [UniProt] |
| Cellular Localization | Cytoplasm, Membrane, Mitochondrion, Peripheral membrane protein. [UniProt] |
| Calculated MW | 54 kDa |
| PTM | Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. [UniProt] |
