ARG24121
anti-HCN4 antibody [N114/10]
anti-HCN4 antibody [N114/10] for Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Rabbit
Overview
| Product Description | Mouse Monoclonal antibody [N114/10] recognizes HCN4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Rb |
| Tested Application | FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| Specificity | ~130kDa. No cross-reactivity against other HCNs. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | N114/10 |
| Isotype | IgG1 |
| Target Name | HCN4 |
| Antigen Species | Rat |
| Immunogen | Fusion protein amino of rat HCN4 |
| Conjugation | Un-conjugated |
| Alternate Names | HCN4; Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4; Hyperpolarization Activated Cyclic Nucleotide-Gated Cation Channel 4; BRGDA8; EIG18; SSS2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HCN4 |
| Gene Full Name | Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 |
| Background | This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. |
| Function | Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. |
| Cellular Localization | Cell membrane, Membrane |
| PTM | Glycoprotein, Phosphoprotein |
