ARG55233

Name: anti-HDAC2 antibody
Brand: arigo Biolaboratories
SKU: ARG55233
Price: 345 USD
Availability: InStock
Rating: 5.0 (1 reviews)

anti-HDAC2 antibody

Ordering Information

Package

Price (USD)

100 μl

345.00

50 μl

245.00

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Datasheet
Review (1)

Overview

Product Description	Rabbit Polyclonal antibody recognizes HDAC2
Tested Reactivity	Hu, Ms
Predict Reactivity	Chk
Tested Application	FACS, ICC/IF, IHC, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	HDAC2
Antigen Species	Human
Immunogen	KLH-conjugated synthetic peptide corresponding to aa. 410-439 (Center) of Human HDAC2.
Conjugation	Un-conjugated
Alternate Names	Histone deacetylase 2; EC 3.5.1.98; HD2; YAF1; RPD3

Application Instructions

Application Suggestion

Tested Application	Dilution
FACS	1:10 - 1:50
ICC/IF	1:10 - 1:50
IHC	1:50 - 1:100
WB	1:1000

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Purification with Protein A and immunogen peptide.
Buffer	PBS and 0.09% (W/V) Sodium azide
Preservative	0.09% (W/V) Sodium azide
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 15182 Mouse HDAC2 GeneID: 3066 Human HDAC2 Swiss-port # P70288 Mouse Histone deacetylase 2 Swiss-port # Q92769 Human Histone deacetylase 2
Gene Symbol	HDAC2
Gene Full Name	histone deacetylase 2
Background	This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. [UniProt]
Cellular Localization	Nucleus. Cytoplasm
Research Area	Cell Biology and Cellular Response antibody; Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody
Calculated MW	55 kDa
PTM	S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. S-Nitrosylation interferes with its interaction with MTA1 (By similarity).